Postdoctoral Fellow- Oncology Discovery - Spring House Pennsylvania

Company: Disability Solutions
Location: Spring House, Pennsylvania
Posted On: 04/21/2024

At Johnson & Johnson Innovative Medicine, we use technology and the power of teamwork to discover new ways to prevent and overcome the world's the most significant healthcare challenges. Our Corporate, Pharmaceutical and Medical Devices teams leverage data, real-world insights, and creative minds to make life-changing healthcare products and medicines. We're redefining outdated healthcare ecosystems and infusing them with transformative ideas to help people thrive throughout every stage of their lives. With a reach of more than a billion people every day, there's no limit to the impact you can make here. Are you ready to reimagine healthcare? Here, your career breakthroughs will change the future of health, in all the best ways. And you'll change, too. You'll be inspired, and you'll inspire people across the world to change how they care for themselves and those they love. Amplify your impact. Join us! The Post-doctoral Research Scientist-Oncology Discovery Hematological Malignancies [focused on Multiple Myeloma (MM)] will work independently on a project designed to further the understanding of MM and hematological malignancy biology with the goal of investigating mechanisms of T cell engager resistance. You will have the ability to work with and learn from experts within discovery oncology research, specialized in cell and molecular biology, flow cytometry, computational biology, and in vivo sciences, while also leveraging additional resources at J&J Innovative Medicine. The length of the position will be 2 years, the candidate is expected to present and publish their research. In this role you will:

• Work with discovery scientists within J&J Innovative Medicine to design and execute studies to further our understanding of mechanisms of resistance to T cell redirection therapeutics (ie. Bispecific/multispecific antibodies and CART), with a focus on the multiple myeloma (MM) disease area
• Integrate internal and external data in the design and interpretation of experiments
• Develop and utilize assays to mimic bone marrow-like conditions
• Investigate MM protein biology
• Use CRISPR/Cas9 screening technologies
• Design and analyze multi-color (6-16) flow cytometry experiments to characterize immune cell function (e.g., celesta, fortessa, symphony)
• Perform advanced molecular and cellular biology techniques (e.g., viral and non-viral cell transduction, Western blot, DNA/RNA isolation, and qRT-PCR)
• Perform functional T cell redirection assays using bispecific/multispecific antibodies and CART cell therapy
• Maintain detailed and organized experimental records and stay compliant on all relevant internal and external training requirements
• Communicate scientific results to multidisciplinary teams including computational biologists, bench scientists, clinicians, and management in an appropriate biological context More...

      

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