Principal Scientist, Global Discovery Chemistry - Spring House Pennsylvania

Company: Disability Solutions
Location: Spring House, Pennsylvania
Posted On: 04/21/2024

Johnson & Johnson Innovative Medicine is recruiting for a Principal Scientist in Global Discovery Chemistry, for our Peptide group in Medicinal Chemistry at our site in Spring House, PA. At Johnson & Johnson Innovative Medicine, what matters most is helping people live full and healthy lives. We focus on treating, curing and preventing some of the most devastating and complex diseases of our time. And we pursue the most promising science, wherever it might be found. Johnson & Johnson Innovative Medicine discovers and develops innovative medical solutions to address important unmet medical needs in oncology, immunology, neuroscience, infectious diseases and vaccines, and cardiovascular and metabolic diseases. We are Johnson & Johnson Innovative Medicine. Our mission drives us. Our patients inspire us. We collaborate with the world for the health of everyone in it. Thriving on a diverse company culture, celebrating the uniqueness of our employees and committed to inclusion. Proud to be an equal opportunity employer. The Peptide group within Global Discovery Chemistry group is committed to the delivery of high-quality drug candidates working across all Therapeutic Areas (TAs). This mission requires deep scientific expertise in a number of disciplines including chemistry, cellular and molecular pharmacology, enzymology, and screening technologies coupled with an ability to work collaboratively with internal and external partners. Building on a strong legacy of success, we are currently seeking an outstanding individual to join our team as Scientist, Discovery Chemistry. This position will be based at our drug discovery site in Spring House, PA. We are seeking an experienced, highly skilled, and motivated chemist with excellent peptide chemistry and medicinal chemistry expertise to shepherd peptide drug discovery programs and advance them toward the clinic. This position will require the candidate to possess and leverage deep knowledge and capabilities to deliver differentiated clinical candidates to the Janssen product development pipeline within our Disease and Pathway Area Stronghold (DAS and PAS) strategy. Using a mix of internal and external resources, the Principal Scientist will partner with key stakeholders in the TAs and other internal groups, represent medicinal chemistry, lead cross-functional project teams, and be co-responsible for building, managing, and delivering high quality clinical molecules. Responsibilities of the Principal Scientist will include: --- As a dynamic medicinal chemist, drive and contribute to the peptide chemistry function for one or more drug discovery projects, working in concert with partners in molecular and cellular biology, pharmacology, computational chemistry, chemistry capabilities, ADME, structural biology, chemical development, and other key functions. --- Work collaboratively with other Janssen drug discovery sites, including Boston, MA, La Jolla, CA, South San Francisco, CA, and Beerse, Belgium, and with Johnson & Johnson Innovation Centers worldwide --- Analyze synthetic routes to designed compounds, screening data, perform literature reviews, design, propose, and execute medicinal chemistry plans, coordinate chemistry and biology data to support compound progression and patent strategies --- Independently designing and synthesizing drug-like peptide molecules utilizing current medicinal chemistry knowledge, including property-based optimization, and an understanding of ADME, pharmacokinetics and optimal physicochemical properties. --- Provide scientific direction and leadership for synthetic and medicinal chemistry activities of internal FTEs. This role may have direct people management responsibilities. --- Supervise and direct synthetic chemistry activities at contract research organizations (CROs) --- Contribute to portfolio and stage-gate reviews, lead the preparation and presentation of dossiers for clinical candidate nomination and compound advancement --- Participate in shaping and implementing strategies that support synthetic and medicinal chemistry growth objectives at Janssen, including academic relations and talent acquisition --- Ensure optimal interaction/communication and provide updates on project status to drug discovery leadership --- Maintain a significant level of productivity in the laboratory setting More...

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