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Senior Director, Protein Engineering - Cambridge Massachusetts
Company: Disability Solutions
Location: Cambridge, Massachusetts
Posted On: 05/08/2024
Working with UsChallenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us .When you join BMS, you are joining a diverse, high-achieving team united by a common mission. The Tumor Microenvironment Thematic Research Center (TME TRC) is focused on developing therapeutic targets at the intersection of tumor, stromal and immune biology within the TME with the goal of enhancing responsiveness to checkpoint blockade and targeted therapies and transforming response and durability rates for cancer patients. Comprising of scientists across multiple disciplines we are responsible for the biology and translational science necessary to support drug development from target identification through to first in human studies.Here, you'll get the chance to grow and thrive through opportunities that are uncommon in scale and scope. You'll pursue innovative ideas while advancing professionally alongside some of the brightest minds in biopharma.At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science. In oncology, hematology, immunology, neuroscience, and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference. As part of the Discovery Biotherapeutics efforts at BMS, the Senior Director of Protein Engineering will play a key role in discovering and delivering a first-in-class and best-in-class Biotherapeutics pipeline. The Senior Director, Protein Engineering, will be responsible for leading a team of 20+ scientists across three Bristol Myers Squibb (BMS) sites located in Cambridge (MA), San Diego (CA), and the San Francisco Bay Area (CA). The primary responsibility will be to design, engineer, and characterize biologic drug candidates, including antibody drug conjugates, bispecific and multi-specific antibodies, and other biomolecule formats to progress BMS's robust pipeline that spans multiple disease areas including oncology, hematology, immunology, neuroscience, and cardiovascular disease. The Senior Director, Protein Engineering, role will be crucial in innovating and advancing protein engineering capabilities, supporting drug development initiatives, and ensuring the success of BMS's research activities.You will work in close collaboration with scientific leaders across the global Research organization and beyond (e.g., Biologics Drug Product/CMC teams) to deliver on our Biologics pipeline. You must have a thorough understanding of biologics modalities with an appreciation of the requirements and processes needed to advance biologics programs (including novel formats) through discovery and into development. A proven track record of establishing and/or using cutting edge protein engineering technologies (either internal or external) to progress an innovative biologics pipeline is key.Responsibilities: - Lead and drive innovation in protein engineering and core platform processes.
- Manage resources for protein design and production to support new drug development technologies and research initiatives.
- Engineer biotherapeutic modalities, including novel formats, identifying, and mitigating risks in protein engineering projects.
- Utilize structural and sequence analysis to guide the design of drug candidates.
- Oversee the optimization, quality validation, and stability studies of drug candidates.
- Make clear and impactful data-driven recommendation on programs.
- Contribute to regulatory filings of biotherapeutics.
- Prepare reports, papers, and patent applications in collaboration with cross-functional scientists and other functional areas.
- Drive timeline planning and decision-making regarding research priorities and project feasibility.
- Manage group budgets, allocate resources efficiently, and ensure cost-effectiveness.
- Lead, mentor, and develop a high-performing team, fostering innovation, collaboration, and continuous learning.
- Engage in strategic planning, setting research priorities, and advancing drug development pipelines, driving continuous improvement.
- Oversee multiple projects, set timelines, and ensure timely delivery of objectives.
- Represent the company externally, engage with key opinion leaders, and present at external scientific meetings.
- Additional responsibilities may include oversee and implement automation for high-throughput plate-based cloning, expression, and purification of biologic drug candidates. Basic Qualifications: Bachelor's Degree with 15+ years of academic / industry experienceOrMaster's Degree with 12+ years of academic /industry experienceOrPh.D with 10+ years of academic / industry experienceAnd 8+ years of leadership experience Preferred Qualifications:
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