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Senior Scientist, Genetics IPS - Cambridge Massachusetts
Company: Disability Solutions Location: Cambridge, Massachusetts
Posted On: 05/08/2024
Working with UsChallenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us .When you join BMS, you are joining a diverse, high-achieving team united by a common mission. The Informatics and Predictive Sciences (IPS) mission is to Pioneer, Partner and Predict to drive transformative insights for patient benefit. IPS conducts applied computational research in areas that include genomic, structural and molecular informatics, computational and systems biology, patient selection and translational biomarker research, and broader fields including knowledge science, epidemiology and machine learning-across the full lifecycle of drug discovery and development and across all therapeutic areas at BMS. We do this in close partnership with scientific and clinical experts in the field, both inside and outside the company." We perform innovative science to empower key data-driven decisions across a rich pipeline of next-generation medicines. In doing so, our work transforms the lives of patients, as well as our own lives and careers.Here, you'll get the chance to grow and thrive through opportunities that are uncommon in scale and scope. You'll pursue innovative ideas while advancing professionally alongside some of the brightest minds in biopharma.Senior Scientist, Genetics IPSAt Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science. In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.We seek a talented computational researcher to use large biobank datasets to identify genetically-defined patient populations that match novel target mechanisms. This role will sit within Informatics & Predictive Sciences, a globaly distributed group driving innovative computational research for discovery and early development within BMS research.A key focus will be to identify genetic markers that define patient sets with a higher probability of successful response to newly discovered BMS targets/therapeutics. This will involve the application of advanced computational approaches in statistical genetics and predictive modeling (e.g. polygenic modeling, rare variant burden tests, disease trajectory analyses) to biobank and other human genetics datasets. It will also include close coordination with discovery and clinical program teams to enable these scientific insights to have meaningful impact on our ability to deliver novel therapies that address unmet medical need. This position offers an exciting opportunity to impact human health through innovative human genomics research, and will enable discovery groups within BMS research to launch novel programs based on causal human biology. It is also an opportunity to work closely with the broader scientific community through pre-competitive collaborations (e.g. FinnGen, UK Biobank, UK Genes & Health), and to publish and present industry-leading work in this area. Location: Cambridge, MAResponsibilities will include, but are not limited to, the following: - Design and perform statistical analyses in biobank / real-world data sets that match drug mechanisms to specific patient populations (e.g. with polygenic scores and rare variants)
- Design and perform analyses of genetic analysis of disease progression with longitudinal clinical data
- Contribute to efforts to build capabilities for integrative analyses across a suite of biobank data resources
- Coordinate with stakeholders across research and clinical to facilitate the use of germline genetics and related biomarkers in future clinical trials
- Communicate findings and recommend follow up actions in multiple settings (including 1:1, seminars, project meetings, and external publications)Basic Qualifications:Bachelor's Degree and 7+ years of academic or industry experienceorMaster's Degeree and 5+ years of academic or industry experienceorPh.D and 2+ years of academic or industry experiencePreferred Qualifications: The ideal candidate will have the following mix of professional and personal characteristics:
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