Senior Scientist, Antibody Discovery Platform Development - Cambridge Massachusetts

Company: Disability Solutions
Location: Cambridge, Massachusetts
Posted On: 05/05/2024

Janssen Research & Development, L.L.C., a division of Johnson & Johnson's Family of Companies is recruiting for a Senior Scientist, Antibody Discovery Platform Development located in Cambridge, MA. At Janssen, we never stop working toward a future where disease is a thing of the past. We're the Pharmaceutical Companies of Johnson & Johnson, and you can count on us to keep working tirelessly to make that future a reality for patients everywhere, by fighting sickness with science, improving access with ingenuity, and healing hopelessness with heart. We focus on areas of medicine where we can make the biggest difference: Cardiovascular & Metabolism, Immunology, Infectious Diseases & Vaccines, Neuroscience, Oncology, and Pulmonary Arterial Hypertension. Visit us: As a member of the In Vivo Antibody Discovery Group, you will be responsible for development and optimization of efficient antibody discovery platforms. As part of platform development effort, you will lead and drive the analysis of antibody repertoire from immunized animals and from enriched CHO libraries. Responsibilities --- Contribute to development and evaluation of emerging technologies and platforms for antibody discovery through repertoire analysis from immunized animals or CHO display library --- Lead antibody generation using CHO display platform to screen immune repertoire --- CHO display library preparation with targeted integration using CRISPR/Cas9 or RMCE --- Regular presentation of data in team meeting, effective communication and coordination of work in highly matrixed project team environment --- This will involve designing and implementing NGS experiments to generate sequence data to characterize the antibody repertoire at different stages of antibody discovery. --- In addition to your primary responsibilities related to repertoire analysis with NGS, you may also be involved in mouse genetic engineering to improve antibody discovery efficiency. --- This may involve techniques such as CRISPR/Cas9 gene editing to introduce specific mutations or modifications to the mouse genome. --- A strong understanding of B-cell isolation methods such as Hybridoma technology and primary B-cell sorting will also be important. --- This is a critical function in a multifaceted Biologics Discovery organization committed to bringing the next generation of biotherapeutic molecules to patients. --- We are looking for a motivated candidate with scientific and technical expertise who can collaborate across discovery areas to bring value to our portfolio of innovative drug concepts. --- Proficiency to lead within a highly coordinated, fast-paced environment will be a significant attribute. --- An additional knowledge base in the areas of oncology, immunology, infectious disease, or cardiovascular disease would be a plus. If this sounds like you, come join our team! More...

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