Senior Scientist, Cheminformatics - San Diego California

Company: Disability Solutions
Location: San Diego, California
Posted On: 05/09/2024

Johnson & Johnson is recruiting for a Senior Scientist, Cheminformatics. This position can be located La Jolla, CA or Spring House, PA. Remote work options may be considered on a case-by-case basis and if approved by the company. At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com/. The Therapeutics Discovery organization is continuing to build key scientific expertise in computational and medicinal chemistry, screening, and pharmacology to partner closely with our outstanding therapeutic area scientists to develop groundbreaking new medicines. We are expanding our capabilities in cheminformatics across multiple drug discovery platforms, including DNA-encoded library (DEL) screening, peptide-display discovery, support for RNA-based therapeutics, parallel medicinal chemistry (PMC), targeted protein degradation, and high-throughput screening (HTS). We are seeking creative, self-motivated informatics and data scientists to join our Cheminformatics team within In Silico Discovery (ISD) to bring their expertise to exciting efforts in drug design across both small molecule and alternative modalities. Join an enthusiastic, diverse, and global community of internal scientists committed to bringing innovative new medicines to patients. As a Senior Scientist in Cheminformatics, you will:

• Work in partnership with scientists in our global discovery chemist (GDC) organization to design, enumerate, and profile DELs.
• Develop AI/ML and physics-based silico models to prioritize DEL molecules for off-DNA synthesis and to screen external libraries to identify new chemical matter.
• Develop data visualizations from internal and external sources, including chemical structures, biological assay data, and other experimental results to discover new trends and enable improved decision-making in discovery projects.
• Develop workflows, scripts, and tools to facilitate the discovery, design, and selection of molecules with improved drug-like properties.
• Mentor junior scientists in ISD, fostering their development and growth.
• Collaborate with other teams including medicinal chemists and focused discovery technology groups.
• Shape and implement strategies that support innovative and efficient drug discovery by researching and incorporating new techniques, modalities, and platforms. More...

      

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