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Associate Director/Sr Research Investigator/Research Investigator, QSP & PBPK Methods - Princeton New Jersey
Company: Disability Solutions Location: Princeton, New Jersey
Posted On: 04/15/2024
Working with UsChallenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us .Quantitative Systems Pharmacology (QSP) & Physiologically Based Pharmacokinetics (PBPK) have become important components of discovery and clinical development. Mechanistic model and data characterization, calibration, and validation are critical aspects of QSP&PBPK modeling approaches needed during model development and application to establish confidence in models, confidence in their predictions, and leverage data to guide modeling efforts in impactful ways. Our QSP&PBPK team has established expertise, impact, and tools to develop, calibrate, and apply QSP and PBPK models. We are searching for a scientist with expertise in model calibration algorithms and pipelines and strong coding experience to guide the team's methodology and technology strategies, as well as future innovation. Expertise with virtual population approaches is highly desired but advanced mathematical or statistical training and experience developing customized Bayesian algorithms would be a reasonable background. This scientist will bring expertise in modeling and calibrating the population variability, characterizing uncertainty, and experience leading scripted toolbox and new method development. Ideally the individual will also have interest in developing and deploying apps and tools for colleagues of various backgrounds as well as adapting approaches from machine learning. The individual will play a critical role unifying the team's technology strategy, maintaining technology and keeping code up-to-date, improving and adapting best practices and maintaining rigor in light of emerging regulatory guidelines for mechanistic modeling, mentoring modelers on the methods and technology, optimizing existing and new methods for efficiency to improve time-to-impact, and help with project deliverables to speed impact as part of a highly efficient, collaborative team. Responsibilities: - Provide leadership for existing model calibration and computing capabilities and future model, technology, and algorithm innovation and development
- Advance novel and rigorous methodologies for population variability calibration, model sensitivity analysis, and prediction uncertainty characterization
- Advance existing and lead development of new tools that can be deployed using parallel resources on compute clusters with thousands of workers to accelerate characterization and calibration of ordinary differential equation models with substantial compute times in high dimensional spaces
- Assist therapeutic area expert modelers to accelerate efforts and ensure timely model development and calibration to impact drug development programs and coordinate technology development
- Maintain, advance, and coordinate codebases and documentation for data integration and analysis as well as model simulation, characterization, and calibration
- Serve as a primary liaison with company Information Technology and coordinate QSP&PBPK group technology strategy
- Partner with external groups to accelerate the internal efforts in key technology areas
- Establish standards of practice within the department
- Align QSP&PBPK technology strategy with organizational priorities
- Network with stakeholders in other functions to facilitate methods, data, and model development and application
- Serve as a subject matter expert to both internal colleagues and the external scientific community
- Stay informed with emerging literature and science in the modeling and simulation sciences
- Build and maintain a personal track record of publication in the area of QSP & PBPK methods
- Maintain an active relationship with colleagues in Clinical Pharmacology, Pharmacometrics, & Bioanalysis at the project level as well as in the advancement of PharmacometricsPosition requirements:
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