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Principal Scientist/Associate Director - RNA Therapy Biology / Program Management - Boston Massachusetts
Company: Society of Exploration Geophysicists
Location: Boston, Massachusetts
Posted On: 05/06/2025
About the RoleQilu Pharmaceuticals, a leading pharmaceutical and biopharmaceutical company in China, with three innovation centers in the U.S., is expanding its RNA therapy team. We seek a highly motivated and experienced scientist to lead efforts in advancing RNA-based therapeutics. This role offers two potential directions based on expertise and career aspirations: RNA Therapy Biology: Focused on developing siRNA therapeutics targeting liver, extrahepatic, and neurological diseases. Program Management: Overseeing drug discovery programs, evaluating new therapeutic targets, and managing cross-functional collaborations.Potential Directions1. RNA Therapy Biology FocusThis track emphasizes leading scientific initiatives in RNA therapeutics, particularly siRNA drug discovery and development.Primary Responsibilities: Oversee multiple programs developing siRNA therapeutics, from target identification to candidate selection. Stay updated on competitive landscapes in RNA-based modalities (siRNA, ASO, mRNA, etc.). Design and execute preclinical proof-of-concept studies in relevant therapeutic areas (liver, extrahepatic, CNS). Manage global CROs and external partnerships, ensuring quality and timely execution. Train and mentor junior scientists, research associates, ensuring adherence to best practices and SOPs. Present findings to project teams, governance bodies, and external scientific audiences.Qualifications: Ph.D. in Biology, Pharmacology, Molecular Biology, or a related discipline with 5+ years of industry experience. Deep understanding of RNAi mechanisms, PK/PD relationships, and oligonucleotide drug discovery. Strong expertise in preclinical model development for RNA therapeutics. Experience managing external collaborations, including CRO partnerships. Excellent communication skills in English (Chinese proficiency is a plus). Strong leadership, organizational, and project management skills.2. Program Management FocusThis track is ideal for individuals with experience in drug discovery program management, target evaluation, and cross-functional leadership.Primary Responsibilities: Identify and assess novel therapeutic targets, ensuring translational feasibility. Coordinate cross-functional teams (biology, chemistry, bioinformatics) to drive projects forward. Develop and implement assays for target engagement, potency, and mechanism-of-action studies. Support drug discovery programs from early-stage research through critical development milestones. Ensure project deliverables are met on time and within budget. Present data and strategic insights to internal stakeholders and external partners. Contribute to publications, patents, and regulatory documentation.Qualifications: Ph.D. in Molecular Biology, Biochemistry, Neuroscience, or a related field with 5+ years of industry experience. Proven track record in program management within biotech/pharmaceutical R&D. Strong background in oligonucleotide therapeutics (siRNA, ASO, mRNA) is preferred. Experience in assay development for drug discovery applications is preferred. Excellent leadership and cross-functional collaboration skills. Ability to thrive in a fast-paced, dynamic research environment.
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