Neuroscience Biology Lead Boston, MA - Boston Massachusetts

Company: manifold.bio
Location: Boston, Massachusetts
Posted On: 04/29/2024

Position
Manifold Bio is seeking an enthusiastic, highly creative neuroscience lead to expand our drug discovery efforts. You will work closely with the founders and R&D leadership to refine our neuroscience strategy and advance pipeline programs treating diseases of the CNS. The ideal candidate will have a strong scientific background and experience leading biologics programs in one or more CNS therapeutic areas (neurodegeneration, neuroinflammation, neuro-oncology, etc). This is a unique opportunity to work with world-class technologists innovating in cutting edge molecular biology and compute approaches to realize the potential of a novel protein engineering platform. You will lead early discovery projects that integrate our novel platform capabilities with both internal and external R&D resources. Together, we'll continue to fundamentally change the current paradigm of drug development through the original vision of massively increasing the throughput of testing protein therapeutics.
Responsibilities

• Guide company level neuroscience / CNS strategy
  
• Evaluate new project/target opportunities and propose POC experiments
  
• Leverage external resources and coordinate internal team members to lead projects from discovery to candidate selection
  
• Coordinate with protein engineering on binder discovery and/or evaluate in-licensing opportunities, considering tradeoffs among target presentation and relation to disease biology
  
• Design screening funnels that integrate our novel mDesign in vivo biologics design platform
  
• Analyze and interpret data to enable decision making
  
• Design development plans to early human PoC, including specifying DC nomination criteria
  
  Required Qualifications
  
  
  
  • Biology Ph.D. or equivalent experience
    
  • Experience designing screening funnels leveraging both in vitro and in vivo assays with a focus on biologics ( 5-10 for Dir. level; 10+ for VP level)
    
  • Previous experience as a team lead or co-lead in an industry setting
    
  • Experience with hybrid drug discovery models blending external and internal R&D workflows
    
  • Highly independent and proactive, excellent communication and cross-functional team coordination skills
    
    Preferred Qualifications
    
    
    
    • Experience with molecules that enhance BBB transcytosis (e.g. 'shuttles')
      
    • Experience and interest in assay development (in vitro/ex vivo/in vivo)
      
    • Experience with preclinical development and clinical trial planning
      
      Why this might be a great role for you
      
      
      
      • You are eager to solve the challenge of CNS delivery of biologics
        
      • You love thinking about how to apply exciting new platforms
        
      • You are excited about starting drug programs from the very beginning
        
      • You want to join a small, agile, highly innovative team
        
        We value different experiences and different ways of thinking and believe the most talented teams are built by bringing together people of diverse cultures, genders, and backgrounds.
        
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