Senior Scientist I, ADC/AOC Conjugation - North Chicago Illinois

Company: AbbVie
Location: North Chicago, Illinois
Posted On: 04/03/2026

Company Description About AbbVie AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com . Follow @abbvie on LinkedIn, Facebook , Instagram , X and YouTube. Job Description Key Responsibilities: Synthesis, purification, and characterization of antibody oligonucleotide conjugates (AOCs) and antibody drug conjugates (ADCs) on mg to gram scale under minimal supervision. Development, optimization, and validation of conjugation protocols specifically for antibody oligonucleotide conjugates. Optimization and validation of formulation buffers for bioconjugates. Application and refinement of automated techniques for AOC/ADC synthesis and purification. Collaboration with cross-functional teams to advance AOC discovery programs from conceptualization to early development. Qualifications Qualifications Bachelors Degree or equivalent education and typically, 10 years of experience, Masters Degree or equivalent education and typically 8 years of experience, PhD and no experience necessary. Demonstrated hands-on expertise in laboratory-scale protein purification using Hydrophobic Interaction Chromatography (HIC), Size Exclusion Chromatography (SEC), Ion-Exchange (IEX), mixed-mode chromatography, and/or affinity chromatography. Experience with GE AKTA FPLC and Unicorn software is preferred. Strong experience in the discovery, design, synthesis, and purification of Antibody Oligonucleotide Conjugates (AOC), including familiarity with associated chemistries and analytical methods. Hands-on experience with relevant analytical techniques such as HIC-HPLC, SEC, IEX, RP-HPLC, and capillary electrophoresis techniques (e.g., CE-SDS, icIEF). Proven problem-solving skills, motivation, enthusiasm, attention to detail, and the ability to thrive in a fast-paced, cross-disciplinary team environment. Superior written and oral communication skills, with a strong record of collaboration and innovation. Preferred: Previous experience with linker chemistry and payload conjugation strategies specific to oligonucleotide therapeutics. Experience troubleshooting or optimizing the stability and delivery of antibody-oligonucleotide conjugates. Additional Information Applicable only to applicants applying to a position in any location with pay disclosure requirements under state orlocal law: The compensation range described below is the range of possible base pay compensation that the Companybelieves ingood faith it will pay for this role at the timeofthis posting based on the job grade for this position.Individualcompensation paid within this range will depend on many factors including geographic location,andwemayultimatelypaymore or less than the posted range. This range may bemodifiedin thefuture. We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligibleemployees. This job is eligible toparticipatein our short-term incentiveprograms. Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, anddeterminable.The amount and availability of anybonus,commission, incentive, benefits, or any other form ofcompensation and benefitsthat are allocable to a particular employeeremainsin the Company's soleandabsolutediscretion unless and until paid andmay bemodifiedat the Companys sole and absolute discretion, consistent withapplicable law. AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled. US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more: https://www.abbvie.com/join-us/reasonable-accommodations.html More...

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