Principal CADD Scientist - San Diego California

Company: Genesis Therapeutics Inc.
Location: San Diego, California
Posted On: 05/09/2025

Genesis Therapeutics is assembling a world-class computational chemistry team to revolutionize drug discovery through cutting-edge machine learning and biophysical simulation. We are seeking a Principal CADD Scientist to join our on-site discovery team in San Diego, working directly with scientists in our state-of-the-art wet lab and with our distributed computational chemistry and CADD science teams across the US.What You Will Do (Key Responsibilities)

• Utilize a combination of industry-standard and proprietary AI-powered CADD tools to guide small molecule drug discovery programs across a diverse target portfolio, including novel targets with limited chemical precedents.
• Use approaches like virtual screening, molecular simulation, and potency and ADMET prediction to support key decision-making in drug discovery efforts.
• Collaborate closely with medicinal chemists in molecular design and the development of project-specific computational approaches.
• Act as a cross-team connector, effectively communicating between our computational chemistry and medicinal chemistry teams to ensure seamless information flow and collaborative decision making.
• Adapt to a fast-paced environment where innovation and quick iteration are encouraged.What you'll bring
  • PhD in Computational Chemistry, Structural Biology, or a related field. This particular role may also be suitable for PhD-level scientists with degrees in organic or medicinal chemistry with extensive experience in the lab, who have transitioned into industry roles in CADD.
  • Deep understanding of structure-based drug design and protein-ligand interactions.
  • Proficiency with industry-standard CADD tools such as MOE, PyMOL, and Schrodinger Suite.
  • Minimum of 5+ years of industry experience as a CADD scientist in pharma or biotech, with hands-on experience in active drug discovery programs.What we offer
    • Competitive Pay
    • Health Care Plans (including Medical, Dental, and Vision, fully covered for the employees)
    • Stock Option Eligibility
    • 401(k) Plan
    • Open PTO Policy
    • Paid Company Holidays
    • Free lunch and snacks at our offices
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