Conjugation Scientist, Biotherapeutic Engineering (BS or MS) - San Diego California

Company: Novartis Farmac--utica
Location: San Diego, California
Posted On: 05/04/2025

Conjugation Scientist, Biotherapeutic Engineering (BS or MS)Job ID REQ-10048864Apr 22, 2025USASummaryInternal Title: Senior Scientist I#LI-Onsite lab roleThe Biologics Research Center (BRC) is seeking a highly motivated scientist with the skills and experience to contribute to advancing ADC drugs to patients in need. This is a great opportunity to join a group dedicated to protein, antibody drug/ antibody drug conjugate discovery. In this role, you will be a member of several multidisciplinary teams in a variety of disease areas, you will support the Novartis conjugation core and be a key player in advancing drug discovery projects.A proven track record of hands-on experience with conjugation chemistry and analytical assays are essential for this role.About the RoleKey Responsibilities:

• Independently conjugate, purify and characterize antibody-drug and/or oligonucleotide conjugates (ADCs/AOCs) using applicable instrumentation for linker-payload conjugation and purification, analytical techniques and characterization assays.
• Coordinate the submission for supplementary biophysical characterization and interpret analytical results with area experts.
• Contribute to the analysis and synthesis of results, design of new experiments and clear communication of scientific progress to project team(s); troubleshoot experiments, optimize conjugation protocols and suggest mitigation strategies to meet project accelerated timelines.
• Work effectively as a member of cross-functional teams to accomplish shared project goals.
• Contemporaneous and accurate documentation of experiments in ELN and registration databases.
• Contribute to patents, publications, and technical reports.
• Proficiency in any of the following: antibody engineering and characterization.
• Experience with expressing, purifying and characterizing hybridomas and recombinant antibodies.
• Extended molecular biology expertise in assays such as cloning and qPCR.
• Experience in cell binding and functional assays for antibody/ ADC/AOC characterization.
• Experience with biological assays such as measuring cytotoxic activity for ADC characterization.
• Ability to analyze experiments in related software such as Microsoft Excel, including basic macro programming; FlowJo; Octet etc.Company will not sponsor visas for this position.Novartis is unable to offer relocation support for this role: please only apply if this location is accessible for you.Novartis Compensation and Benefit Summary:The pay range for this position at commencement of employment is expected to be between: $85,400 and $158,600/year; however, fluctuations in the job market may necessitate adjustments to pay ranges during this period. Further, final pay determinations will depend on various factors, including geographical location, experience level, knowledge, skills, and abilities. The total compensation package for this position may also include other elements, including a sign-on bonus, restricted stock units, and discretionary awards in addition to a full range of medical, financial, and/or other benefits (including 401(k) eligibility and various paid time off benefits, such as vacation, sick time, and parental leave), dependent on the position offered.Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Ready to create a brighter future together?Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up.The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status.Accessibility & Reasonable AccommodationsThe Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or to perform the essential functions of a position, please send an e-mail to us.reasonableaccommodations@novartis.com or call +1(877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.Division Biomedical ResearchBusiness Unit Pharma ResearchLocation USAState CaliforniaSite San DiegoCompany / Legal Entity U175 (FCRS = US175) Novartis Institutes for BioMedical Research, Inc.
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